Driver Location in Speaker Box?

My question:

Does the location of the driver on the front baffle of a sealed speaker box affect subwoofer performance or lifespan?

I am building a sealed box for an Infinity 1230w and am debating on whether to center the driver on the front baffle or if it is ok I would like to push the driver to one side of the box as far as possible (does this give the driver an unequal pressure from behind?). It's not a matter of life and death, just trunk practicality.

Thanks

P.S. - I haven't cut the hole yet, waiting for advice because I don't want to screw things up.

I forgot to mention. The box is 21.75" wide x 14.5" tall x 9.5" deep in exterior dimensions. It have also cut 2 braces, one to brace the front panel and on to brace the rear panel from the top banel to the bottom panel.

Location speaker on the baffle board doesn't affect the performace.  Speaker sees the internal volume as it is.

Ok cool, thanks. That's what I thought and was hoping to hear but wanted to make sure first.

I like to offset the cutout in a box that size if its possible for the situation.  It makes it easier to build in a crossbrace at the center of the box.  Like the following illustration but using only one sub instead of two:

In your box, the center areas of the front and rear baffles are the points most likely to flex.  A brace from front to rear as close to center as you can get it is in order.  The full structure brace shown above accomplishes the same task as I described.  Even though front to rear is braced at the extreme top and bottom, the braces are joined with a rigid vertical member on both ends, forming the equivalent of a complete side baffle.  You get the same results if you were to join front to back with a single rigid piece of wood placed at the center of the box.

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Build the box so that it performs well in the worst case scenario and, in return, it will reward you at all times.

Yup. that's pretty well exactly what I did except without the "+" in the middle length wise. Just letting the silicone dry overnight... test tomorrow