How to run speaker wire for 4 channel amp

I'm about to install a 4 channel amp in my car, and I am wondering how to best wire it. I'm going to put the crossovers in the trunk with the amps. Now, I've always known to put power on one side of the car (this is usually best on the same side of the car as the battery) and then you run the interconnect down the other side of the car. As for the speaker wire, it really would be easiest to run the left speakers on the left side of the car, and right speakers on the right side of the car. I'm sure this is safe to do if you put some seperation between the speaker cable and the power cable, to avoid induction. But, does anybody know how far they have to be apart to keep the power from feeding back into the speaker wire? I appreciate it.

Zip tie 'em together... It won't matter, in fact it doesn't even matter with RCA cables... I run ALL my wires down one side of the car, (except the left side speakers...) and I have no noise whatsoever.It all reminds me of something that Molière once said to Guy de Maupassant at a café in Vienna: "That's nice. You should write it down."

Wiring after amplification is much less critical in regards to  inductance than signal input wiring.  Your speaker wiring may be run as you see fit.Build the box so that it performs well in the worst case scenario and, in return, it will reward you at all times.

So you only have to seperate the interconnect from the power? That's good to know, and will make things a lot easier than what I was anticipating. I appreciate it.