I have a whine, any suggestions?

I have a whine and can't figure out what is causing it..I was wondering if anyone has any suggestions on a possible fix. I can get rid of the noise if i disconnect the RCA's for the front speakers at either the HU or the amp.I have tried a higher quality pair of RCA's just run acroos the interior of the car to the amp and the noise is worse. I have tried grounding my amp at 3 different locations in the trunk of the car with no fix,although the last move I made did quiet it down some.My current equipment consists of an Alpine HU,Focal 165V2's in the front,Focal 690CV's in the rear and a TRU T4.65 amp. In the front speaker install,I did not run new wires from behind the head unit and through to the door.I left factory wiring intact and connected one end to the crossover and the other end I spliced to the wires behind head unit and ran heavier wire from behind head unit to rear of car where amp is.Power and signal wires are run on opposite sides of the car.The car is a 99 Accord Sedan.I was wondering if any of the following scenarios are causing this problem being that is eems to be only occuring with front signal.

1-Amp ground not grounded at an optimal location

2-Getting some kind of interference through the crossovers for the front speakers

3-Interference coming in by using factory wires from crossover to behind head unit where I spliced haevier wire to run to rear of car to the amp.

4-ground for HU from factory harness causing problem,possibly re-ground to firewall

Just a note-The TRU amp replaces an Alpine amp and I also had the same whine as I do now,I just never dug this deep into the troubleshooting.It just seems odd that when I disconnect front speakers it goes away.although when the whine is present,I can hear it through all apeakers.

Any help/suggestions would be greatly appreciated.

Thanks

Dave

First I'd try regrounding the head unit.  If you'd like, it sometimes helps to run the deck's ground wire to the amp ground.  Also check all the factory grounds under the hood- including the negative battery terminal.

LATEST UPDATE:

I ran a wire directly from head unit to ground term on battery,no fix.

I ran a wire directly from amp ground to car battery,no fix.

I will now prepare to re-run all my speaker and RCA cables and see if that eliminates the problem.

I must go meditate,because I fear the task at hand.

Will post results after I have all of that fun!!!

Dave

Add cheese?

or

move the crossovers and see if the sound disappears.

It is getting to that point.I think a big block of moldy cheese would at least take my mind off of the problem.It would also keep people out of my car,so they would not be able to hear the whine.

Thanks for the suggestion forbidden.I think when I re-route the cables I will try to move the x-overs into the car instead of being in the doors.

If the cheese doen't help (and I for one think that is an excellent suggestion) try grounding the outer ring of the RCA cables.  At the amp side is probably easiest to access.  This would be a band-aid solution, but if it solves the whine it could mean you have a problem in your HU.  

OH, did you try swapping the RCA input at the amp front to rear?  I assume the whine moves to the rear (follows the RCA cables)?  If it stays on the front, then your problem is not in the HU or the cables, it's in your amp OR in the speaker wires between the amp and the speakers themselves.