Thanks Stevdart - those are very helpful tips.
I will do that LOC search but can you tell why you (and even my amp's manufacturer's tech guy if I remember correctly) believe the PAC-OEM2 is going to do a better job of converting high level to low level? It seems it would be the other way around - there's so much more room in the amp and whatever electronics are needed could be custom balanced for that amp.
Whatever the reason, it's good new because I'm looking for reasons to go with the PAC-OEM2 instead of high levels directly in to the amp. From our discussions on PriusChat, it seems the gain controls on the PAC-OEM2 are the best way to solve an increase in touchscreen beep problem that occurs in a Prius after adding an amp (beeps are routed through the audio system even when the radio is off).
Regarding engine noise - I would take your advice (only worry about it if it happens) but it's a consideration that might (but hopefully won't) prevent me from placing the PAC-OEM (LOC) where I really want it: near the amp where I can still get at it to fine tune the beep volume after install.
But since you say the only place to worry about picking up engine noise will be between the head unit and the LOC, placing the LOC in the dash minimizes the amount of wiring exposed to engine noise pickup. Is that because audio downstream of the LOC will be sent by RCA cables, or is it because the audio is at that point low-level? But I should wire under the assumption there won't be any if I understand you and it sounds like using your twisted speaker wire to send high level audio from the head unit to the LOC in the back near the amp is the way to go.
Any advice regarding wires from the amp to the crossovers to the speakers? If you're absolutely sure I don't need to worry about engine noise with those it would be easier to run the right speaker wires up the right side of the car and the left side up the left side.
But if there IS any chance of engine noise, I could run all the speaker wires up the left side and get the right wires to the right side by sending them through the dash area.
To help answer that question, here is what's going up the right side of the car:
1. PAC-OEM2 12v on (but ONLY if I place the PAC in the dash and hopefully I won't be doing that.) Or possibly the 20 gauge 12-v on you mentioned if the PAC one isn't reliable and I can't find one at the back of the car near the amp.
2. Composite XM cable - all the wires necessary to power and send signal from the special Toyota Prius XM receiver (a Solaris part but integrates just as well into the Prius touchscreen - see PriusXM.com, way better than any other XM solution for the Prius!) up to the touchscreen.
3. XM antenna (from the XM receiver in the back with the amp up to the antenna I will (hopefully only temporarily) be placing on the dash.)
The aux battery is in the back of the Prius where I'll be putting the amp so no amp power line (other than maybe that 12-v on) will have to be run up either side.
I suppose I could run speaker wires both ways, start out using ones up the right side and switch to the ones up the left side and through the dash if I have any engine noise problems? Hate to run wire through the dash area though if I don't have to. Thanks again for your help.