Bridge four channel amp, other channels?

If I bridge 2 channels, from a four channel amp, can I still use the remaining two channels to connect two other speakers/subs as usual?

I am asking because I have a 12" sub in my car, and I am thinking of getting two 5.25" subs for the interior. The 5.25 subs rms is 100 watts (4 ohms), and the four channel amp I want to get is listed:

Does this mean that I will I be able to bridge 2 channels to the 12" sub sending 225w rms to it, and connect the remaining channels to the two smaller subs sending 110w or 80w rms to them?? Please help,    Thanks!