1 dvc 2 ohm sub and 1 dvc 4 ohm sub

You'd probably be better off wiring a single sub.. different woofers will respond to the same input differently.. as the woofers move differently, depending on the phase of the subs, they will be fighting each other.

I've seen isobaric enclosures that have accomplished this okay though.  Series each woofer, then parallel them together for a net of ~2.5 ohms.

This still isn't ideal, but with seperate chambers my primary reservations are assuaded.

Go ahead and wire them like I mentioned above and see how it does. 

Out of curiosity, what subs are they?