wiring door speakers

Hello,

I am setting up to wire several new speakers into my doors and I have a question.

When wiring groups or speakers together from the same amp channel is the impedance as critical as with subs? I am planning to run 2- 6", 2- 5x7, 2- 4" and 2 tweets with the 4s and tweets on one amp and the 6s on another. Should I be wiring the groups in series to keep the ohms up or not worry about it to much. I am using a RF T8004 to power the larger front speakers and a smaller second amp for the others. The 6s Im running are 4ohm, the amp is 1 ohm stable but I am concerned about too much power going down the line to the smaller speakers. I think an 8 ohm load would be ideal and I can do the math for that but Im not sure if Im over thinking this a little.

Thanks for any input!